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Genetic Testing & Addiction

How Genetic History Impacts Addiction

The science behind genetic testing used as a method to understand addiction may be relatively new. Still, it is making a significant impact. It is not a perfect fix when it comes to resolving or preventing addiction, but it helps in understanding addiction and treatment. If medical professionals fully understand their patient’s history and makeup, they are better equipped to help them. At Reflections, we firmly believe in fully understanding and treating each patient. When we work with genetic testing, we are not going to get a magic book with all of the answers. However, we will better understand each patient. This will help the patient in their recovery and they will have a better chance at maintaining sobriety.

When someone is already suffering from addiction, our goal is to understand their history and how they got there. Is there anything in their history and genetic make-up that made them susceptible to addiction? In a study published by the National Institute of Health (NIH), they noted, “Addictions are moderately to highly heritable.”* This does not mean that every person with addiction in their heritage will suffer from addiction. The risks are higher but there a lot of factors. The possibility of addiction can greatly depend on the availability of an addictive agent, exposure to the addictive agent, and their choice to take it (NIH)*. Nonetheless, the reality is that there can be a greater risk and this is important to keep in mind. Identifying genes that make a person susceptible to addiction make it easier to then identify tools to help prevent relapse.

Genetic testing is only one piece of a very complex puzzle in resolving the problem of addiction.

-Robert Parkinson, U.S. News

Understanding Addiction with Genetic Testing

At Reflections Recovery Center, Lisa Parsons is the Medical Director. Dr. Parsons is particularly interested in understanding every aspect of the patient’s physical makeup to fully help them. It helps to look at the DNA of patients to understand if they are carrying any vulnerability in their genetics. If so, did something occur in their life that turned that vulnerability on? Someone that is prone to stress and anxiety might be fine until something traumatic happens. Part of their genetics that drive the stress and anxiety can be what then makes them susceptible to substance abuse. The testing our team does, including Dr. Parsons, looks at these factors and check for imbalances. Once an imbalance is identified, we can begin treatment to regain a proper balance again. As with any treatment, nothing is a perfect or a total fix on its own. Nonetheless, regaining balance in any area is hugely important and helpful.

DNA Methylation

One of the genetic structures we look at is DNA methylation. Methylation is a chemical reaction that occurs in every cell and tissue in our bodies.* It is, understandably, an incredibly important part of our health. As methylation is a process that involves DNA, understanding it and our genetic history is so important. Within the brain, there are reuptake proteins which act like vacuum cleaners. They live between brain cells that take away neurotransmitters to create balance. Balance is incredibly important for health in every aspect and especially so when it comes to methylation.

When someone is undermethylated, with too many reuptake proteins, they may feel chronically depressed, tense, and anxious. Some people may feel suicidal or a lack of care for their own life or safety. With too few reuptake proteins (overmethylation) someone might feel fidgety, tense, have a hard time relaxing, or have a hard time sleeping. With either imbalance, this can leave someone susceptible to addiction as they try to cope with these symptoms.  Methylation is a process that significantly impacts our health and lives more than most of us realize.

There are, of course, many other aspects of genetic testing to look at. This is just a brief example of what we will look at to thoroughly help each patient.

Treating Addiction with Genetic Testing

Not everyone suffering from addiction carries the same genes indicating addiction. Likewise, not everyone with vulnerable genetics will suffer from addiction. For those that are vulnerable or carry “addiction genes”, understanding their genetic makeup will help. Genetic testing allows us to determine if a patient is suffering from any number of disorders. We can see what in their genetic makeup may have made them vulnerable to addiction in the first place. It can also help to determine what is the best course of action for treatment. The more precisely we can understand genetics, the better we can tailor treatment to each individual.

In an article for U.S. News, Robert Parkinson writes, “Genetic testing is only one piece of a very complex puzzle in resolving the problem of addiction.”* This is incredibly important for any person, or loved one, dealing with addiction to know. Genetic testing is not going to provide a clear map for curing addiction and ensure there is never a relapse. What it will do is provide clarity and direction in some aspects. Addiction may be a complex puzzle and genetic testing may only be one part of that puzzle, but each piece is still vital. We want each patient to maintain sobriety, not just become sober for a short amount of time. If we are going to meet this goal, then we have to look at everything we can to help them.

*Resources:
NIH – Genes and Addictions
Revolution Health – What is Methylation and Why Should You Care?
U.S. News – Genetic Testing for Addiction